Roundup is a large-scale database of orthology. The orthologs are computed using the Reciprocal Smallest Distance (RSD) algorithm. This algorithm detects more (and more accurate) orthologs than reciprocal best blast hits and gives each ortholog a score based on evolutionary distance.

Roundup results are integrated with terms from Gene Ontology and gene names from NCBI. Roundup is a living dataset: the underlying genomes and the orthologs computed from them are updated regularly.
Read a tutorial (PDF) about the locally-installable version of the RSD algorithm then download the RSD algorithm package.

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