Download Orthologs for a Pair of Genomes

Documentation and Example


Download Archived Releases

Download the orthologs for the current (and past) Roundup release and the genomes used to compute them. You can download the orthologs as a compressed text-format file containing all the orthologs for a given combination of divergence and e-value parameters. You can download the genomes used in a Roundup release as a compressed archive containing a FASTA file for every genome.

Releases prefixed with 'qfo_' are special releases of data generated as a part of the Quest for Orthologs, a worldwide collaboration of orthology researchers aimed at standardizing, evaluating, and improving ortholog inference. These releases contain orthologs for the Reference Proteomes of the Quest for Orthologs group, computed using a divergence of 0.8 and e-value of 1e-5, which can be downloaded as a compressed OrthoXML file.

Release 4

Release 3

Release 2

Release qfo_2013_04

Release qfo_2011_04

Download Software

Need orthologs for a genome not in Roundup? Download and run the RSD algorithm on your computer:

For those interested in the how the Roundup website or computational pipeline works, the code for Roundup is available at: